Table 2 Regression models for determinants of COVID-19 vaccine acceptance among HCWs recruited from the participating hospitals in Ismailia, Egypt, during March and April 2021

 Gender (male/female)

− 0.657

0.007^*

0.518 (0.321–0.837)

 Education

0.384

0.005^*

1.469 (1.123–1.921)

 Having children (0/1)

− 0.040

0.888

0.961 (0.555–1.665)

 Do you think SARS-CoV-2 is natural? (0/1)

0.402

0.087

1.495 (0.943–2.370)

 Have you ever taken influenza vaccine previously? (0/1)

1.184

< 0.001^*

3.268 (2.048–5.217)

 Anxious about infection (0/1)

0.101

0.772

1.106 (0.635–1.925)

 Do you trust the healthcare facility that you work in? (0/1)

0.527

0.087

1.692 (0.927–3.087)

 Constant

− 1.895

0.004^*

0.150

< 0.001^*

 Has your information regarding COVID-19 vaccines helped you to make your decision? (0/1)

0.680

0.025^*

1.973 (1.088–3.579)

 Do you think that the vaccine plays a role in stopping the pandemic? (0/1)

0.672

0.048^*

1.959 (1.007–3.810)

 Do you think that the vaccine plays a role in reducing disease complications? (0/1)

0.271

0.492

1.311 (0.605–2.839)

 Do you think that the vaccine has serious side effects? (0/1)

− 0.226

0.478

0.798 (0.428–1.489)

 Do you think that the vaccine is effective? (0/1)

0.954

0.008^*

2.597 (1.282–5.262)

 Do you think that the vaccine is safe? (0/1)

1.838

< 0.001^*

6.286 (3.132–12.619)

 Do you think that the evidence regarding vaccine safety and effectiveness is sufficient? (0/1)

0.925

0.020^*

2.521 (1.154–5.508)

 Do you think that the vaccine can infect you with the virus? (0/1)

− 0.473

0.623

0.623 (0.339–1.143)

 Are you a vaccine opponent in general? (0/1)

− 1.717

0.180

0.180 (0.062–0.517)

 Constant

− 2.649

0.071

0.071

< 0.001^*